Class: Anticholinergic Agents
VA Class: AU350
CAS Number: 1235-82-1
Brands: Akineton
Introduction
Antimuscarinic antiparkinsonian agent.a b
Uses for Biperiden Hydrochloride
Parkinsonian Syndrome
Adjunctive treatment of all forms of parkinsonian syndrome;a b more efficacious in postencephalic and idiopathic cases than in arteriosclerotic types.b
Relieves muscle rigidity, reduces sweating and salivation, improves gait, and to a lesser extent, tremor.a b
Drug-Induced Extrapyramidal Reactions
Control of extrapyramidal reactions induced by neuroleptic agents (e.g., phenothiazines).a b
Biperiden Hydrochloride Dosage and Administration
Administration
Oral Administration
Administer orally 1–3 times daily.a b
Dosage
Available as biperiden hydrochloride, dosage expressed in terms of the salt.a
Adjust dosage carefully according to individual requirements and response.b
Adults
Parkinsonian Syndrome
Oral
Initially, 2 mg 3–4 times daily; if tolerance develops, or dosage is inadequate, titrate dose to maximum of 16 mg daily in 3–4 divided doses.b
Drug-Induced Extrapyramidal Reactions
Oral
Usual dosage: 2 mg 1–3 times daily.a b
Prescribing Limits
Adults
Oral
Maximum 16 mg daily.a b
Special Populations
No special population dosage recommendations at this time.a
Cautions for Biperiden Hydrochloride
Contraindications
Narrow angle glaucoma.a b
Bowel obstruction or megacolon.a b
Known hypersensitivity to biperiden or any ingredient in the formulation.a b
Warnings/Precautions
Warnings
CNS Effects
Large or toxic doses or usual doses in patients with excess susceptibility may produce marked CNS disturbances (e.g., mental confusion, euphoria, agitation, disturbed behavior).a
Use with caution in patients with epilepsy.a
Ophthalmic Effects
Increased ocular tension associated with antimuscarinic use; however, such effect not reported with biperiden.a c Use with caution in patients with glaucoma.a
Cardiovascular Effects
Possible tachycardia; use with caution in patients with cardiac arrhythmias.a c
GU Effects
Possible urinary retention; use with caution in patients with prostatic hypertrophy.a c
Specific Populations
Pregnancy
Category C.a b
Lactation
Not known whether biperiden is distributed into milk.a b Caution advised if biperiden is used.a b
Pediatric Use
Safety and efficacy not established.a
Common Adverse Effects
Dry mouth, blurred vision, drowsiness, dizziness, constipation, agitation, mental confusion.a b
Interactions for Biperiden Hydrochloride
Specific Drugs
Drug | Interaction | Comments |
|---|---|---|
Alcohol | Possible additive CNS effectsa | Avoid concomitant usea |
Anticholinergic agents | Increased risk of adverse anticholinergic effectsa b |
Stability
Storage
Oral
Tablets
25°C (may be exposed to 15–30°C).a Protect from light.a b
ActionsActions
Exhibits atropine-like blocking action on parasympathetic-innervated peripheral structures, including smooth muscle.a
Competitively inhibits acetylcholine or other cholinergic stimuli at autonomic effectors innervated by postganglionic nerves.a c
Weak peripheral anticholinergic agent with antisecretory, antispasmodic, and mydriatic effects.b
Exhibits nicotinolytic effects.a b Nicotinolytic effects >6 times that of atropine.b
Advice to Patients
Potential for drug to impair mental alertness or physical coordination; use caution when driving or operating machinery until effects on individual are known.a
Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs and dietary or herbal supplements, as well as concomitant illnesses.a
Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.a
Importance of informing patients of other important precautionary information. (See Cautions.)
Preparations
Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.
Routes | Dosage Forms | Strengths | Brand Names | Manufacturer |
|---|---|---|---|---|
Oral | Tablets | 2 mg | Akineton (scored) | Abbott |
Disclaimer
This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.
The American Society of Health-System Pharmacists, Inc. and Drugs.com represent that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. and Drugs.com make no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. and Drugs.com do not endorse or recommend the use of any drug. The information is not a substitute for medical care.
AHFS Drug Information. © Copyright, 1959-2011, Selected Revisions October 2007. American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland 20814.
References
a. Par Pharmaceutical, Inc. Akineton (biperiden hydrochloride) tablets prescribing information. Spring Valley, NY; 2001 Nov.
b. AHFS drug information 2006. McEvoy GK, ed. Biperiden. Bethesda, MD: American Society of Health-System Pharmacists; 2006:1255.
c. AHFS drug information 2006. McEvoy GK, ed. Antimuscarinics/Antispasmodics General Statement. Bethesda, MD: American Society of Health-System Pharmacists; 2006:1257-64].
More Biperiden Hydrochloride resources
- Biperiden Hydrochloride Side Effects (in more detail)
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- Biperiden Hydrochloride Use in Pregnancy & Breastfeeding
- Biperiden Hydrochloride Drug Interactions
- Biperiden Hydrochloride Support Group
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